TagsTransfersAbout the authorPaul VegasShare the loveHave your say Everton threaten Spurs plans for Boca Juniors midfielder Wilmar Barriosby Paul Vegas10 months agoSend to a friendShare the loveEverton are being linked with Boca Juniors midfielder Wilmar Barrios.Barrios has been linked with several of Europe’s top clubs, including Real Madrid, Tottenham and AC Milan.And Everton have now joined the race to land the Colombia central midfielder.He has a €20m (£18m) in his Boca Juniors contract, which could be triggered in January by the Toffees.Marca says the 25-year-old is up for moving to Europe from Argentina and a switch to Goodison Park would allow him to settle in alongside pal Yerry Mina, who joined from Barcelona in the summer.
“Additional efforts, including those noted in this report, are needed to reverse the loss of critical habitat and declines in boreal caribou populations.”The department is required under the Species At Risk Act to assess provincial and territorial efforts to assist the recovery of caribou populations.In April, Environment Canada found significant problems. In every province, agencies that issue permits for forestry or energy development aren’t required to conform to the federal Species At Risk Act.That earlier report also noted that little conservation is taking place on the ground. Measures in almost every case are still being planned or drafted.That situation continues. The new report lists dozens of ongoing negotiations, draft plans and provincial promises to restore caribou populations to sustainable levels, but there are few fully implemented protected areas.Planning is good, said Florence Daviet of the Canadian Parks and Wilderness Society. Action would be better. OTTAWA, O.N. – An Environment Canada report says that despite much talk on preserving caribou habitat, little progress has been made to close gaps in the protection of the threatened species.The agency says not much has changed since a coast-to-coast survey in April.“Despite the progress being made, the gaps in protection, as described in the first progress report, remain,” says the report issued Friday. “They were supposed to be doing this planning and talking since 2012,” she said. “They’ve had a lot of time to talk.”Barry Robinson, a lawyer with the group Ecojustice, pointed out that Friday’s report was itself almost two months overdue. So are many of the protection measures that should be in place by now, he said.“We still don’t have any range plans in Alberta, which were to have been done by October 2017.”Many governments, including Alberta, have announced ambitious plans for new protected areas. But almost all remain in draft form or remain unimplemented, he said. “The big gaps are still there.”Caroline Theriault, an Environment Canada spokeswoman, said the report shows many steps have been taken across the country to support caribou recovery.“Since the last report was published in April, provinces and territories have made some progress on protection plans and on the ground recovery efforts,” she said in an emailed statement. “We recognize that more needs to be done, and we are already taking action.”The latest assessment of woodland caribou suggest that 81 percent of Canada’s herds are in decline. Loss of another one-third of the population is expected “in the near term.”The main threat to their numbers is alteration of habitat, which reduces a herd’s productivity and allows access by predators.Caribou conservation is often seen to be in direct conflict with forestry and energy and the jobs they generate. In late March, Alberta delayed its own caribou range plans over economic concerns.Robinson said that sooner or later, legislation will oblige federal Environment Minister Catherine McKenna to step in and override provincial regulations with an emergency protection order.“The minister has not done the one thing she is legally required to do, which is to recommend a protection order when the province hasn’t protected the required habitat.”(THE CANADIAN PRESS)
Varanasi: Dismissed BSF jawan Tej Bahadur Yadav’s nomination as the Samajwadi Party candidate against Prime Minister Narendra Modi from Varanasi Lok Sabha constituency was rejected on Wednesday, poll officials said. Yadav was served notices Tuesday by the Varanasi returning officer over discrepancies in the two sets of nomination papers submitted by him. In the first set of papers on April 24, he had mentioned that he was dismissed from the Border Security Force. Also Read – India gets first tranche of Swiss account details under automatic exchange framework On April 29 he submitted a second set of papers this time as the Samajwadi Party nominee for the Lok Sabha seat but did not give out this information. He was also required to submit a no-objection certificate from the BSF, giving reasons for his dismissal. Yadav accused the BJP of resorting to “dictatorial steps” to stop him from fighting elections. “My nomination was rejected today even though I had furnished the NOC from BSF that was required by the RO, he claimed. I am a farmer’s son and I was here to raise the voices of farmers and jawans,” he told reporters. His counsel Rajesh Gupta said, “We will approach the Supreme Court”.
The Golden State Killer, who terrorized Californians from Sacramento to Orange County over the course of a decade, committed his last known murder in 1986, the same year that DNA profiling was used in a criminal investigation for the first time. In that early case, officers convinced thousands of men to voluntarily turn over blood samples, building a genetic dragnet to search for a killer in their midst. The murderer was eventually identified by his attempts to avoid giving up his DNA. In contrast, suspected Golden State Killer Joseph James DeAngelo, who was apprehended just last week, was found through other people’s DNA — samples taken from the crime scenes were matched to the profiles his distant relatives had uploaded to a publicly accessible genealogy website.You can see the rise of a modern privacy conundrum in the 32 years between the first DNA case and DeAngelo’s arrest. Digital privacy experts say that the way DeAngelo was found has implications reaching far beyond genetics, and the risks of exposure apply to everyone — not just alleged serial killers. We’re used to thinking about privacy breaches as what happens when we give data about ourselves to a third party, and that data is then stolen from or abused by that third party. It’s bad, sure. But we could have prevented it if we’d only made better choices.Increasingly, though, individuals need to worry about another kind of privacy violation. I think of it as a modern tweak on the tragedy of the commons — call it “privacy of the commons.” It’s what happens when one person’s voluntary disclosure of personal information exposes the personal information of others who had no say in the matter. Your choices didn’t cause the breach. Your choices can’t prevent it, either. Welcome to a world where you can’t opt out of sharing, even if you didn’t opt in.Yonatan Zunger, a former Google privacy engineer, noted we’ve known for a long time that one person’s personal information is never just their own to share. It’s the idea behind the old proverb, “Three may keep a secret if two of them are dead.” And as far back as the 1960s, said Jennifer Lynch, senior staff attorney for the Electronic Frontier Foundation, phone companies could help law enforcement collect a list of all the numbers one phone line called and how long the calls lasted. The phone records may help convict a guilty party, but they also likely call police attention to the phone numbers, identities and habits of people who may not have anything to do with the crime being investigated.But the digital economy has changed things, making the privacy of the commons easier to exploit and creating stronger incentives to do so.“One of the fascinating things we’ve now walked ourselves into is that companies are valued by the market on the basis of how much user data they have,” said Daniel Kahn Gillmor, senior staff technologist with the ACLU’s Speech, Privacy and Technology Project. A company can run along, not making a cent, but if it has a large user base and reams of private information about those users, then it’s valuable — and can be sold for millions. Companies that collect more data, keep that data, and use it to make connections between users are worth more. Sears, Roebuck and Co. may have been able to infer when you bought a gift from their catalog for a friend who lived in another town, but Amazon has more reason (and more ability) to use that information to build a profile of your friend’s interests.We all saw this in action in the recent Cambridge Analytica scandal. The privacy of the commons is how the 270,000 Facebook users who actually downloaded the “thisisyourdigitallife” app turned into as many as 87 million users whose data ended up in the hands of a political marketing firm. Much of the narrative surrounding that scandal has focused on what individuals should be doing to protect themselves. But that idea that privacy is all about your individual decisions is part of the problem, said Julie Cohen, a technology and law professor at Georgetown University. “There’s a lot of burden being put on individuals to have an understanding and mastery of something that’s so complex that it would be impossible for them to do what they need to do,” she said.Even if you do your searches from a specialized browser, tape over all your webcams and monitor your privacy settings without fail, your personal data has probably still been collected, stored and used in ways you didn’t intend — and don’t even know about.Companies can even build a profile of a person from birth based entirely on data-sharing choices made by others, said Salome Viljoen, a lawyer and fellow with the Berkman Klein Center for Internet and Society at Harvard. Imagine new parents signing up for a loyalty card at their local pharmacy and then filling all of their child’s prescriptions there. The information collected every time they scan that loyalty card adds up to something like a medical history, which could later be sold to data brokers or combined with data bought from brokers to paint a fuller picture of a person who never consented to any of this.So does that mean that, in addition to locking down our own privacy choices, we need to police the choices of our friends and family? No, said Cohen, Gillmor and Viljoen. In fact, the privacy of the commons means that, in some cases, your data is collected in ways you cannot reasonably prevent, no matter how carefully you or anyone you know behaves.Take, for instance, Equifax, the credit-rating company that lost control of the data of 143 million people last year. Those people weren’t necessarily members of Equifax. Instead, the company collected data from other companies the people chose to do business with, and much of that business was stuff people can’t get by without, like renting or owning a home. Or, alternately, consider Facebook, again. That company has admitted it tracks the online behavior of people who never intentionally engage with it at all, thanks to partnerships with other websites. (Like many sites, FiveThirtyEight has this kind of partnership with Facebook. Our pages talk to the social network in several ways, including through ads and comments, and because of the embedded “Like” button.) If hounding every person you’ve ever cared about into adopting encryption tools like PGP sounded like fun, you’ll love living in a van down by the river with no internet access.1And I hope you’re prepared to buy the van with cash, because if you need credit, the credit check the dealer runs could hand your information to Equifax again.Instead, experts say these examples show that we need to think about online privacy less as a personal issue and more as a systemic one. Our digital commons is set up to encourage companies and governments to violate your privacy. If you live in a swamp and an alligator attacks you, do you blame yourself for being a slow swimmer? Or do you blame the swamp for forcing you to hang out with alligators?There isn’t yet a clear answer for what the U.S. should do. Almost all of our privacy law and policy is framed around the idea of privacy as a personal choice, Cohen said. The result: very little regulation addressing what data can be collected, how it should be protected, or what can be done with it. In some ways, Gillmor said, online privacy is where the environmental movement was back in the 1950s, when lots of big, centralized choices were hurting individuals’ health, and individuals had little power to change that. “I don’t even know if we have had our ‘Silent Spring’ yet,” he said. “Maybe Cambridge Analytica will be our ‘Silent Spring.’”
Leeds United manager Marcelo Bielsa has denied making any contact with Manchester City or Tottenham Hotspur as regards to signing some of their players on loan.The new Leeds boss hasn’t spoken to any of the two club’s managers about any form of loan deals.Bielsa enjoys a very good relationship with both Pep Guardiola and Mauricio Pochettino, with the latter playing under him during his stint as the manager of Argentine club Newell’s Old Boys.“I don’t think it would have been a good thing to do to use a personal relationship of respect and love you have for both of them for a professional reason. You don’t have to manipulate the professional decisions.” Bielsa said, according to Yorkshire Post.Meanwhile, Sky Bet Championship promotion hopefuls Aston Villa are planning to sign two Newcastle United players on loan before the loan window closes on August 31.Pochettino admits Wanyama remains in his Spurs plans Manuel R. Medina – September 14, 2019 Kenyan international, Victor Wanyama, was the protagonist of a summer transfer saga, but in the end, he is set to stay at Tottenham Hotspur.The Villans want Isaac Hayden and Ciaran Clark to join them on loan for the entire duration of the 2018-19 season.Hayden has been linked with a move away from St. James Park all summer but a permanent moved failed to materialize before the close of the Premier League transfer window last week.Stoke City are also believed to be interested in signing the former Arsenal midfielder on loan.Aston Villa want former centre-back Ciaran Clark to join the club on loan. Clark left Villa Park in 2016 to sign for Newcastle on a permanent basis.
Related Items:daylon joseph, eddinton powell, engineer, fortisalberta, FORTIStci Recommended for you FortisTCI ready for the building boom and consumer demand for electricity; plans in place and new ones coming says CEO Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 03 Jul 2015 – Daylon Joseph, an engineer with Fortis TCI will leave for a one year on the job training stint in Canada and among the experiences for him will be designing and maintaining electrical and distribution standards and solving technical problems associated with design and operation of lines and equipment. FortisTCI in a media release explained that this opportunity is among the benefits of having a link to the Fortis Group of Companies. Over the year, Daylon will work temporarily at FortisAlberta and the other six months at Fortis Canadian Utilities. CEO of FortisTCI, Eddinton Powell congratulated Daylon Joseph as he explained that the electricity industry is undergoing unprecedented transformation which brings challenges and creates a range of opportunities; he added that “our workforce must be ready to meet these challenges and opportunities.” Facebook Twitter Google+LinkedInPinterestWhatsApp Premier salutes FortisTCI on round the clock work to restore electricity and visits 14 resorts after June 4 black out Editorial: Listen to your Mama
KUSI Newsroom, April 11, 2018 Posted: April 11, 2018 Man wanted in connection with random stabbing attack in Hillcrest KUSI Newsroom SAN DIEGO (KUSI) — Authorities reached out to the public Wednesday for help in identifying a man believed responsible for an apparently random stabbing attack that left a pedestrian severely wounded in Hillcrest last weekend.The suspect, a thin Latino who appeared to be in his mid-20s to mid-30s, was seen walking around in the area of Essex and Richmond streets in San Diego for about a half-hour early Sunday evening, seemingly looking for someone to fight, according to police.He eventually threw a rock at a 51-year-old pedestrian and walked off, but returned short time later and attacked the same victim with a knife, stabbing him in the head and neck, police said. The assailant then fled to the west.Medics took the victim to a trauma center for treatment of severe wounds. The man, who remained hospitalized this morning, is expected to survive.A surveillance camera near the scene of the attack captured images of the suspected attacker.Anyone with information about the case is asked to call San Diego County Crime Stoppers at (888) 580-8477 or contact the agency online at sdcrimestoppers.org. Tipsters may remain anonymous and could be eligible for a reward of up to $1,000. Categories: Local San Diego News FacebookTwitter
Due to the winds, trees continue to fall in and along the road creating hazardous driving conditions. The pilot car escorts will remain in place until the wind event stops even though fire activity is low at the moment. If you travel on the highway, please use caution and observe the direction of the pilot car drivers. Facebook0TwitterEmailPrintFriendly分享Winds were gusty Sunday along the Sterling Highway and are predicted to continue blowing through Monday. In many areas adjacent to the highway, the fire burned very hot resulting in trees weakened by fire damage. Conditions are still dynamic and can change quickly. Delays can last from 45 minutes up to a several hours at times.
Like many publishers in the B2B sector, SourceMedia continues to center its growth strategy around digital media and data-focused marketing solutions. The company underwent a corporate rebranding to that effect earlier this month, introducing a new website and logo. “SourceMedia ABM makes SourceMedia’s audience data actionable,” said Witte in a prepared statement. “Our deep relationships with our audience members give us an ideal platform for understanding the interests and purchasing patterns of the bankers, advisers, and accountants in our professional communities.” In an extensive interview with Connectiv’s Matt Kinsman, Marcus Whitte, SourceMedia’s VP of integrated marketing and demand generation, says, “Account based-marketing, at its very basic level, is taking a group of names that make up an account … and doing very targeted messaging to them. If you were just looking at this basic level, a lot of companies are grabbing names and doing targeted marketing to those lists. We take it one step further because in our umbrella of brands, we’ve got some really robust first party data that we can pull from.” Combining insights from machine learning techniques with SourceMedia’s proprietary audience data, SourceMedia ABM will aim to provide clients with sales-ready leads by delivering customized messaging to individual influencers within specific audience segments. The B2B publisher and events firm, whose brands in the finanical, technology, and healthcare sectors include American Banker, PaymentSource, The Bond Buyer, and Health Data Management, among many others, has announced the launch of SourceMedia ABM, a new capability that will allow clients to target individual senior-level professionals at pivotal moments in the customer journey. The benefits to this are two-fold, Whitte tells Kinsman. For one, SourceMedia’s customer data platform can now unify records for the same individual across multiple database platforms, providing a much more comprehensive view of an individual’s interests and consumption habits. Those insights can then be applied to other individuals with similar behaviors to reach them in the most efficient and effective ways possible. SourceMedia is expanding its client offerings to provide the latest service sweeping the B2B media and information industry: account-based marketing. So, what actually is account-based marketing? ABM campaigns, depending on the client’s objectives, can include custom content, distribution across multiple platforms and types of content (including social media), and near-real-time reporting and engagement scoring. In February, SourceMedia relaunched its company-wide digital publishing platform to open up mobile optimization and native advertising integration, and hired AnnMarie Wills to the newly created role of VP of audience and data, reporting directly to chief digital and marketing officer Minna Rhee.
BSE closes points 78.91 down on Jan 141.1K views00:00 / 00:00- 00:00:0000:00BSE closes points 78.91 down on Jan 141.1K viewsBusinessNew Delhi, Jan 14 (ANI): Trading at the Bombay Stock Exchange today closed 78.91 points down to stand at 27,381.46. At the National Stock Exchange the Nifty closed 10.95 points down to stand at 8,288.45. Bajaj Finance Limited and DABUR were among the top gainers of Group A with an increase of 7.76% and 7.48% along with NHPC and MARICO with an increase of 6.49% and 6.09% respectively, while the top losers of Group SSLT and HINDALCO with a decrease of 8.29% and 6.24% along with FSL and DCBBANK with a decrease of 5.36% and 4.36% at the close of the markets. The Auto sector is up 81.91 points at 18,914.59 while the banking sector is down 54.04 points at 21,366.59 and the reality sector is down 10.92 points at 1,492.18. The Indian currency is down 0.06% at Rs 62.18 per dollar.Ventuno Web Player 4.50New Delhi, Jan 14 (ANI): Trading at the Bombay Stock Exchange today closed 78.91 points down to stand at 27,381.46. At the National Stock Exchange the Nifty closed 10.95 points down to stand at 8,288.45. Bajaj Finance Limited and DABUR were among the top gainers of Group A with an increase of 7.76% and 7.48% along with NHPC and MARICO with an increase of 6.49% and 6.09% respectively, while the top losers of Group SSLT and HINDALCO with a decrease of 8.29% and 6.24% along with FSL and DCBBANK with a decrease of 5.36% and 4.36% at the close of the markets. The Auto sector is up 81.91 points at 18,914.59 while the banking sector is down 54.04 points at 21,366.59 and the reality sector is down 10.92 points at 1,492.18. The Indian currency is down 0.06% at Rs 62.18 per dollar.
Listen at WEAA Live Stream: http://amber.streamguys.com.4020/live.m3uDonald Trump’s meeting with HBCU presidents is receiving dubious reactions at best, in the wake of the antics of Education Secretary Betsy DeVos and White House staffer Kellyanne Conway. We’ll open the phone lines to get the response of our listeners to Trump’s HBCU photo op…410.319.8888. Also, my conversation with veteran White House correspondent April Ryan, who is covering her fourth president.These stories and much more on AFRO’s First Edition with Sean Yoes, Monday through Friday, 5-7 p.m.
As the average age of gamers increases, the medium matures, and we start to reach the limit of how much game-based ultra-violence we need to consume. The marketplace has therefore started to embrace more experiential games. These games aren’t exactly flooding the stores yet, but it’s gotten to the point where some of them are notable releases and they are more than just a break between the release of Modern Warfare and Battlefield. One of the best games in this genre (if you can call it that) is Journey, which was released on PSN earlier this month.The blandly name game sounds like something straight out of the MUD era, but it’s anything but. The game is starkly beautiful, with striking sound and absolutely no unnecessary adornment. You have two buttons — most of which serve no purpose for large parts of the game — and then one stick to control the character and another for the camera. The character is faceless, nameless, mute, and vaguely feminine, with no goal aside from a destination off in the distance. The game has no directions, no tutorial, and while it’s multiplayer you can’t choose your companions and you can only communicate with them through musical notes that the character emits.Speaking of the multiplayer — it’s oddly fantastic. With no way to communicate with other players aside from emitting ghostly chords, jumping in the air, or running in circles around them, people that I regularly mute when playing other games are transformed into docile, helpful companions that I spent large parts of my quest with.If this sounds unlike any game you’ve played lately, then you’re starting to catch on. It combines the beauty and loosely defined goals of Flower with exploration and unparallelled simplicity. You can’t die, you can’t kill anything, and there are not RPG-like features.I could say more about the game, but frankly I think I’d be doing you a disservice by over-explaining it. It’s a wonderful experience that will last you about two hours. I, like many people, wish it could have been longer, but if that would have meant diluting the experience or feeling less connection between the character and myself, then I’m glad the developers didn’t feel the need to add fluff to the game just to increase playtime.There’s not much else to say aside from that you should set aside some time, mute your phone, and give Journey a try. Even if you don’t buy into the whole experiential thing, this is the best looking game I’ve played in years, maybe ever.
© 2014 Phys.org (Phys.org) —The KickSat project is getting very close to a launch date. Originally scheduled to go up Sunday March 16th, the Kickstarter project organized by Zachary Manchester, has been postponed. It is now scheduled to be boosted into space by a SpaceX rocket sometime between March 30 and April 2. KickSat co-creator, team launches new ‘Pocket Spacecraft’ project on Kickstarter Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The KickSat will be sent into space in a Dragon capsule aboard a SpaceX rocket (the rest of the cargo will go on to the International Space Station). Shortly after liberation from its capsule, KickSat will begin spinning freely in space and turning on its radios. Sometime later the Sprites will be spun off into space where they will begin performing whatever they have been individually programmed to do. Each will have a gyro, a magnometer, solar collectors, radio, sensors and a chip to run preprogrammed code. Data from each Sprite will be broadcast back to Earth on a shared radio frequency—each has been programed to wake-up, perform its work, then go back to sleep, on a random time-table to reduce the number of Sprites talking at the same time. Anyone who wishes to do so can purchase a small amount of equipment (antenna, noise amplifier, software, etc.) to listen in as well. Those on the project will be listening and collecting data from a site in Ithaca, New York. The KickSat project is as much a concept as a physical entity, it consists of a box that looks like a CD jukebox (it’s also about the same size) and holds what are called Sprites—small (about the size of a saltine cracker and weighing just 5 grams) flat satellites. Once in space, the KickSat will spin around and eject the 104 Sprites it will be carrying, where they will operate independently 200 miles above the Earth for a few days to possibly a week before burning up upon reentry. The project is an attempt to give ordinary people access to space science by allowing for launching very tiny, inexpensive satellites, with costs spread across hundreds of others that are nearly identical to it.The KickSat project was first launched in 2011 as a Kickstarter project, and received more than double its goal of $30,000. Backers got their names engraved on one of the KickSat panels (which have been published on the Kickstarter page) and if they donated enough, their own Sprite. Owners were given firmware development kits to allow for programing functionality. Citation: KickSat nearing launch date despite another delay (2014, March 14) retrieved 18 August 2019 from https://phys.org/news/2014-03-kicksat-nearing-date.html More information: www.kickstarter.com/projects/z … craft-in-space/posts
Iran is set to launch eight new thematic television channels after the The Islamic Republic of Iran Broadcasting (IRIB) approved the plans.IRIB chief Ezzatollah Zarghami announced it would launch new channels covering entertainment, news and science. This follows the launch of the country’s first home shopping channel, which launched earlier this year.
CAR BURNT OUT AT BALLYARNETT COUNTRY PARK – DUFFYCOUNCILLOR SANDRA DUFFYDerryNA MAGHA GAC “Speaking to parents they said it was very lucky no one was hurt as this car was driven through the park.“The police have been informed and the neighbourhood team are following up on information.“A bad news story we could be doing without,” added Cllr Duffy.CAR BURNT OUT AT BALLYARNETT COUNTRY PARK – DUFFY was last modified: July 9th, 2016 by John2John2 Tags: Sinn Fein councillor Sandra DuffySINN Féin Councillor Sandra Duffy has condemned those who left a burnt out car in Derry this week.She said: “Another bad night for our community.“A car was stolen and burnt out at Ballyarnett Country Park, with much of the green around the park destroyed with it rallying thought it.“This all took place as Na Magha GAC were holding a competition on their newly built site. ShareTweet
By Daniel Jepson, Guest Contributor and Chris Wood, Senior Analyst In last week’s article on epigenetics, we began with a brief discussion of the enormous expectations that were placed on the Human Genome Project (HGP)—such as, that its results would lead to the end of disease—and how those expectations ultimately went unfulfilled because of course, things are never that simple. More importantly, in this case, genes are only part of the story. To quote briefly from that article: “Little did the community know at the time that the project [i.e., the HGP] would only uncover a small portion of what’s really going on in our genome. They were only scratching the surface. What the architects of that project once dismissed literally as junk surrounding our genes is proving far more vital than anyone ever expected—in fact, it may hold the very keys to understanding evolution itself. When scientists began the HGP, they were expecting to find approximately 100,000 protein-coding genes to account for the complexity of our species. What they found instead was that humans only have about 25,000, about the same number as fish and mice. In fact, according to biologist Dr. Michael Skinner, “the human genome is probably not as complex and doesn’t have as many genes as plants do.” That’s sort of a problem, because if we humans are supposed to be the complex species we hold ourselves out to be, then why don’t we have as many genes as an oak tree? Maybe because genes are only part of the story.“ That article went on to discuss how our epigenome—the second layer of structure above the genome, comprised of methyl groups and histones, that changes throughout our lives—can turn our genes on and off and control the degree to which they are expressed. Cool stuff—and a very important budding area of science. But today we’d like to bring the focus back to the genome itself, more specifically to a study of the genome called ENCODE. When the HGP was finished, all scientists really had was a linear sequence of three billion DNA base pairs—in essence, just a set of boring letters consisting of As, Gs, Cs, and Ts. What was needed was something to bring those letters to life and translate them into an instruction manual for actually building a person; then we’d be better able to understand the roots of disease and generate treatments. It happened on September 5, 2012. That was the day when one of the most ambitious international science projects you may have never heard of revealed the fruits of its labor: a collection of 30 papers simultaneously published in the journals Nature, Genome Research, and Genome Biology. Taken together, they provided the results from a multiyear research endeavor—involving over 400 scientists from 32 labs around the world—known as the ENCODE Project. ENCODE, or the “Encyclopedia of DNA Elements,” was designed to pick up where the HGP left off. It sought to annotate the specific regions of the genome that are used in the various cells of the human body and to catalogue the biochemical products of this activity. A key takeaway from the ENCODE project is that even though our genes only account for approximately 2% of our genome, the bulk of the rest of our DNA—which used to be called “junk DNA” because it was thought to serve no real purpose—actually performs crucial regulatory functions. Think of them as switches attached to a particular gene that determine whether or not it will be expressed. Scientists have long been aware of such DNA configurations, but thought their number was on par with the number of genes. It turns out, however, that there are millions of such regions throughout the genome, linked to each other (and to the protein-coding genes) in an extremely complicated hierarchical network. (The metaphor of a “hairball of wires” was offered by one ENCODE scientist.) But the goodies from ENCODE don’t stop there. “It was one of those too-good-to-be-true moments.” That’s what Ewan Birney, a biologist and leading scientist from the ENCODE project consortium, had to say about one of the insights gleaned by the efforts of his team. Back to the HGP for a moment. Much of the excitement that followed the project’s completion a decade ago had to do with the notion that since we now knew how the genome was “supposed” to look, we could identify the genes whose mutations were responsible for certain diseases and devise an appropriate remedy. As noted earlier, however, things aren’t that simple. Genes are only part of the story. We know that from the results of studies that were designed to correlate genetic mutations with specific diseases (known as Genome-Wide Association Studies, or GWAS). In the majority of cases, it was found that disease-correlated DNA variants lay in the vast noncoding regions of the genome, rather than in the genes themselves. With limited understanding of the actual functional processes performed by this DNA, science has been largely unable to come up with an appropriate remedy in situations where the original DNA message has been altered. But thanks to ENCODE, we may be on the way to overcoming this obstacle. A key finding from the project—the one that caught Birney’s attention—was that many of the mutations associated with disease are located in DNA regions to which the ENCODE project was able to assign a specific functionality. In particular, many mutations were found to be located in areas of our DNA known as “promoter” and “enhancer” regions—sequences that, while not coding for protein themselves, are responsible for turning genes on and off within a cell. “[This] is a really big deal,” said Bradley Bernstein, an ENCODE scientist. “I don’t think anyone predicted that [this] would be the case.” So now a whole host of new possibilities for gene therapy will begin to open up. When we can identify the biological processes in the cell that result from a mutation, it becomes much more likely that we can formulate an effective treatment. ENCODE has already identified several hundred regions of DNA that should be of interest to researchers studying specific diseases, and this number will only increase over the next few years as the huge amounts of data generated by the project continue to be analyzed. The project has also identified the function of many noncoding RNA molecules (i.e., RNA molecules other than messenger RNAs, which are an intermediate step in the creation of a protein). Casey Extraordinary Technology subscribers need no introduction to RNAi, an extremely exciting therapeutic technology that’s based on a particular type of noncoding RNA known as small interfering RNA (siRNA). But you may not have heard of a new approach that’s appeared on the scene in recent years: microRNA therapeutics. MicroRNA (miRNA) is a close cousin of siRNA, and its implications for the biotechnology landscape are no less significant. Since their discovery little more than a decade ago, these little molecules have already been widely implicated in the development of several types of cancer: some miRNAs are overexpressed in cancer cells, while others are missing entirely. Not surprisingly, there has been a widespread effort to leverage this insight into therapeutic remedies, and some miRNA-based products have already entered Phase II trials. As biotech investors, we must remember that tomorrow’s breakthroughs will result from events taking place around us today. In order to stay ahead of the market, we must be vigilant in identifying these causes before their effects have been fully brought to light. The ENCODE project, with its “too good to be true” moments, provides a good starting point. While it has received considerably less public fanfare than the Human Genome Project, for the alert investor it points the way toward a whole host of potential new breakthroughs. To stay up to date with all the fascinating new developments in the world of biotechnology, give Casey Extraordinary Technology a risk-free trial run today.
You’ve made this mistake before—sometime between the age of 15 and 25. I can almost guarantee it. And it probably involved a good-looking girl… or boy. Whatever your preference. You took someone for granted and chased after someone new. Then they both dropped you. One big bank is making a similar mistake. Only it’s not chasing tail. It’s chasing customers. A few years back Bank of America began buying every “Bank of Your Little Town” it could. With some 5,000 retail branches across the US, it seemed serious about retail banking. If not, why bother operating all those branches? Meanwhile, it put the moves on Merrill Lynch. Problem is, retail customers just don’t like Bank of America. J.D. Power ranked it dead last in four of 11 regions across the nation this year. And as Bloomberg Business reported, “Bank of America Corp. ranked worst among its peers in retail customer satisfaction in states where it has the most branches, California and Florida….” Part of the problem is that is behaves like an investment bank toward its customers. Back in 2013, Bank of America began phasing out its drive-through windows. A retired bank executive shared a rumor with me: it’s closing drive-through windows to force customers into the branch so they can sell Merrill Lynch products. I’m inclined to believe him. In March, we made a rare trip into a Bank of America branch in Florida to deposit a large check from the sale of our home. The branch manager swooped us into his office and began pitching investment products the minute we walked in. I know; it’s just one example. But they’re hassling long-term customers every day. People don’t like it. But they don’t know there’s a simple, easy-to-execute alternative. First, keep enough cash at your bank to pay your bills. Nothing more. A small local bank that will cover ATM fees when you travel is your best bet. That takes care of your administrative needs. Second, take the remainder of you cash and start your own Bank of Me. This cash should earn a robust return with minimal risk and no hassles. I stand firm in my belief that about one-third of your portfolio should sit in low-risk, liquid, cash-like instruments. But near-negative interest rates negate any safety offered by FDIC-insured accounts. Your cash is just sitting there, withering away. Now is the time to start your own bank. You might be thinking, “This guy is nuts. I’m an engineer (or teacher, fireman, dentist… insert your profession). I don’t have the time or the know-how to start my own bank.” Rest assured, it takes minimal time, and you can bring yourself up to speed right now by reading one special report: Bank of Me. We lay out the process and the specific investments for you. My wife and I took our cash out of Bank of America’s claws. Now we have enough at our local bank to meet monthly expenses. No hassles there, and they call us by name. There’s even a drive-through. And the rest of our cash is carrying its own weight once again. I’d love to show you how to do the same. Click here to learn how to fire your bank.
South Korea is flashing warning signs of a global recession… South Korea is known as a “canary in the coal mine” for the global economy. The country is a major exporter of cars, mobile phones, and personal computers. It’s also the 11th-largest economy in the world. It has a bigger economy than Australia, Russia, Spain, or Mexico. Last month, South Korean exports plummeted 15.8%. It was the country’s largest monthly drop since 2009. It was also the tenth month in a row that South Korean exports dropped from the previous year. Many South Korean companies blame the huge drop in exports on China’s slowing economy. China is, by far, South Korea’s largest trade partner. The country sends 25% of its exports to China. • China’s slowing economy is dragging down the entire region… Last year, China’s economy grew at its slowest pace since 1990. And last month, China’s services sector grew at its slowest pace in seven years. China’s factory output also fell for the eighth straight month in October. Yesterday, Bloomberg Business said China’s manufacturing activity hasn’t been this slow since the global financial crisis. Factory orders in Indonesia, Malaysia and Taiwan are shrinking as well. The bad economic data pushed Asia’s major stock markets down on Monday. China’s Shanghai Composite Index fell 1.7%. Japan’s Nikkei Index fell 2.1%. • U.S. investors also got bad news yesterday… Last month, the ISM Manufacturing Index fell to its lowest level in three years. This index measures the health of the U.S. manufacturing sector. It was the fourth straight month that U.S. manufacturing activity fell. Manufacturing makes up 12% of the U.S. economy. Economists and investors watch the manufacturing sector for clues about where the broad economy is headed… Casey readers know manufacturing profits are falling. Two weeks ago, machinery manufacturer Caterpillar (CAT) reported awful third-quarter results. The company’s quarterly sales were 19% lower than a year ago. Caterpillar expects sales to drop again in 2016. It would be the fourth year in a row the company’s sales have dropped. That’s never happened before in Caterpillar’s 90-year history. Caterpillar sells the tractors, bulldozers, and cranes that build the “real” economy. Like South Korea, many investors consider Caterpillar a bellwether for the global economy. Caterpillar’s customers aren’t buying much right now, which points to trouble. • A weakening global economy is bad for U.S. stocks… Since bottoming in March 2009, the S&P 500 has gained 211%. At 80 months and counting, the current bull market is 30 months longer than the average bull market since World War II. However, E.B. Tucker, editor of The Casey Report, says the mini stock market crash in August was the beginning of the end of the bull market. He explained why in a recent issue of The Casey Report. We believe the era of asset prices soaring on a wave of easy credit is over. Last month’s major stock market decline is the start of a very tough time for stocks and the economy… The market has recovered in the past two weeks. But we think it’s only temporary. In other words, we’re in the middle of a “dead cat bounce.” It’s looking a lot like 2007. To fight the global financial crisis, the Fed cut its key rate to effectively zero in December 2008. It has left rates at effectively zero ever since. This has made it extremely cheap to borrow money… Seven years of easy money has caused prices to soar. Prices for commercial property, bonds, and stocks have all hit record highs, thanks to the Fed. At some point, the U.S. stock market will fall back down to Earth. When that happens, everything from blue chips to penny stocks will plummet. But overpriced stocks will probably fall the hardest… “They’ll do everything they can to push the price of gold down”… This statement was made by keynote speaker and trend forecaster Gerald Celente at the 2015 Casey Research Summit. Find out what Mr. Celente has to say about gold manipulation… the Federal Reserve’s hidden scheme… and how you can protect yourself from it right here. Regards, Justin Spittler Delray Beach, Florida November 3, 2015 We want to hear from you. If you have a question or comment, please send it to email@example.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful. Double Your Money Guarantee Right now Steve Sjuggerud is urging folks to buy 3 tiny gold stocks with 10X potential. And he’s so certain, that he’s giving a “Double Your Money Guarantee” until MIDNIGHT TOMORROW. Learn more here. Recommended Links — • The flood of cheap money has sent restaurant stocks soaring… The Dow Jones U.S. Restaurants & Bars Index has gained 256% since the bull market in U.S. stocks started six years ago. And despite a mostly flat market in 2015, restaurant stocks continued to perform well. As a group, they’re up 19% in 2015, compared to just a 2% gain for the S&P 500. Many major restaurant stocks are now very expensive. For example, pizza chain Papa John’s (PZZA) has a price-to-earnings (PE) ratio of 41 right now…Starbucks (SBUX) has a PE ratio of 35…and burrito chain Chipotle (CMG) has a PE ratio of 38. The S&P 500’s PE is just 22. (A high PE ratio means a stock is expensive.) Yesterday, Bloomberg Business noted that investors are betting against Papa John’s stock. The number of shares being shorted — a bet that the stock will fall — has risen to 5 percent of those outstanding, near the highest level in six years, according to data compiled by Bloomberg and Markit Ltd. The investors are wagering that Papa John’s will have a tough time sustaining its lofty price-to-earnings ratio… E.B. Tucker agrees that Papa John’s stock is way too expensive. I’ve been baffled by Papa John’s for a long time. The stock price trades at 27 times free cash flow. That’s a tremendous premium for a fast food company. That’s what investors pay to own companies that produce groundbreaking cancer drugs or some other life-changing technology. It’s not the price you should pay to own a pizza chain best known for its garlic butter dipping sauce. Bloomberg Business reports that short sellers are also targeting other major restaurant stocks. Shake Shack Inc., the burger chain that went public in January, saw short interest soar after its stock price more than doubled. In that case, investors are betting that its valuation has gotten way ahead of its expansion plans: The chain boasts a $1.65 billion market value despite only having 74 locations as of September. Noodles & Co., which has a PE ratio of 39.1, also is heavily shorted. • Expensive stocks will fall the hardest during the next crash… According to a useful metric, the CAPE ratio, U.S. stocks are 59% more expensive than their historic average. In fact, U.S. stocks are almost as expensive as they were at their 2007 peak. Since the 2008 financial crisis, global central banks have printed trillions of new currency units (dollars, yen, euros, yuan). Instead of producing real growth, companies and investors have simply used these currency units to buy assets like stocks, oil fields, and office buildings, making these assets very expensive. Almost nothing is cheap right now. This isn’t the time to be aggressive with your portfolio. It’s a time to be conservative. It’s a time to build up a large cash position, so you can buy bargains after the next correction or crash. You might even consider shorting very expensive stocks as a way to profit from the coming downturn. We also think everyone should own some physical gold. Gold is the ultimate form of wealth insurance. It’s preserved wealth through every kind of crisis imaginable. It will preserve wealth during the next crisis, too. If you want to truly “crisis-proof” your wealth, we recently published a book just for you… Going Global 2015 is our financial crisis survival guide. It shows you how to preserve and even grow your wealth during recessions, stock market collapses, and every financial disaster in between. Thousands of people have already paid $99 for this important book. Today, we’re offering it to you for just $4.95. We’re practically giving this book away for one simple reason: we hope you’ll do business with us again. And if you read Going Global 2015, we’re confident you will. The strategies and tips in this book could mean the difference between going broke during the next crisis and coming out richer than ever. Click here to learn more. Chart of the Day Restaurant stocks have pulled away from the rest of the market this year… Today’s chart shows the performance of the S&P 500 versus the Dow Jones U.S. Restaurants & Bars Index. This index tracks the performance of many U.S. restaurant companies. It follows major restaurant stocks such as Starbucks, Buffalo Wild Wings (BWLD), McDonald’s (MCD), and Panera Bread (PNRA). The chart starts in March 2009, when the bull market in U.S. stocks began. As you can see, restaurant stocks basically tracked the broad market for the past six years. They started to separate from the pack this year. The U.S. Restaurants & Bars Index is up 19% so far this year. The S&P 500 is up only 2%. Many major restaurant stocks have become incredibly expensive during this rally. We think some of these stocks will be the first to fall during the next crash. –
Subscribe Now New Jersey Voters Likely Just Approved Legalized Marijuana 3 min read Guest Writer Get 1 Year of Green Entrepreneur for $19.99 Phil Murphy, the Democratic nominee for governor, was emphatic about his commitment to legalizing marijuana. He won by a wide margin. November 16, 2017 New Jersey may have decided more than just the governor’s race in the election held this month. They have put the Garden State on the path to becoming the eighth U.S. state to allow recreational marijuana sales. As pointed out last month, a vote for Democrat Phil Murphy meant a vote for creating a state-regulated adult-use marijuana industry. During the campaign, Murphy promised to sign a bill creating a legalized marijuana market in New Jersey during his first 100 days in office. That bill already is moving through the state Legislature.And this hasn’t been a kind of, maybe sort of thing. Murphy has been clear about his intentions on marijuana.“The criminalization of marijuana has only served to clog our courts and cloud people’s futures, so we will legalize marijuana,” Murphy said after winning the Democratic primary earlier this year. “And while there are financial benefits, this is overwhelmingly about doing what is right and just.”Murphy won 56 percent of the vote, with 42 percent going to Republican Kim Guadagno.Related: Jeff Session’s ‘Guidance’ Cited by Maine’s Governor In His Veto of Legal Marijuana BillWhat happens nextMurphy will be inaugurated governor in January 2018. The bill legalizing recreational marijuana sales in New Jersey is still working through revisions in the state Legislature.The “within 100 days” promise actually originates with Senate President Stephen Sweeney. Sweeney, who controls which bills come before the full Senate, has vowed to have the bill before Murphy within the first 100 days of his administration.For his part, Murphy has said he will sign it. His argument is that criminalization of marijuana has destroyed many lives, particularly in minority communities. In the final debate before the election, he said New Jersey has the dubious honor of having “the widest white, non-white gap of persons incarcerated in America.”He blamed much of that on low-end drug crimes involving marijuana. On his website, Murphy also said that legalizing marijuana would free police to focus on more violent crimes.In all of this, Murphy is the polar opposite of his predecessor, Republican Gov. Chris Christie. Christie often railed against legalized marijuana. During the run-up to his bid for the Republican presidential nomination, he vowed to “crack down and not permit” legalized marijuana if elected president.Related: Cannabis Industry Rallies to Overcome Unique Legal Barriers to Recovery From Northern California FiresVirginia decriminalizationThe victory of Democrat Ralph Northam in the Virginia’s governor’s race also could lead to changes in that state’s marijuana laws. While stopping short of legalization, Northam has argued that possession of small amounts of marijuana should be decriminalized. He has addressed the issue from the standpoint of racial discrimination and the financial impact on the state.In a letter to the Virginia State Crime Commission sent earlier this year, Northam wrote that marijuana laws and enforcement have been “disproportionately harmful to communities of color.” He also noted the state spends $67 million on marijuana law enforcement, which he noted is enough to send 13,000 more kids to pre-K school.Follow dispensaries.com on Instagram to stay up to date on the latest cannabis news. dispensaries.com Add to Queue –shares Easy Search. Quality Finds. Your partner and digital portal for the cannabis community. Image credit: Eduardo Munoz Alvarez | Getty Images Cannabis Opinions expressed by Entrepreneur contributors are their own. Next Article Green Entrepreneur provides how-to guides, ideas and expert insights for entrepreneurs looking to start and grow a cannabis business.
Billionaire investor Carl Icahn was mad as hell and wasn’t going to take it anymore. Until today, that is.In a letter to the SEC, Icahn said he is officially giving up his campaign to defeat Michael Dell’s effort along with buyout firm Silver Lake Partners to purchase the computer company he founded and take it private. Icahn opposed Dell’s bid for Dell Inc. — which was recently upped to $24.6 billion — because he believes it undervalues the company.In his letter, Icahn said that he had determined it would be “almost impossible” to influence any outcome other than the company’s board voting in favor of Dell’s bid on September 12. “We have therefore come to the conclusion that we will not pursue additional efforts to defeat the Michael Dell/Silver Lake proposal, although we still oppose it and will move to seek appraisal rights,” the letter says.Related: Dell Founder’s New Buyout Bid Wins Initial Shareholder ApprovalEarlier this summer, Icahn and another Dell investor, Southeastern Asset Management, formulated a rival offer that would see shareholders tender 1.1 billion shares at $14 per share — more than Dell and Silver Lake’s initial bid which they eventually sweetened to $24.6 billion in July. “While we of course are saddened at our losing the battle to control Dell, it certainly makes the loss a lot more tolerable in that as a result of our involvement, Michael Dell/Silver Lake increased what they said was their ‘best and final offer,'” Icahn’s letter says.In an odd twist, Icahn — who has been active on Twitter recently tweeting about his support for tech giant Apple — also used the SEC letter as a way to recruit additional Twitter followers.”If you are incensed by the actions of the Dell Board as much as I am, I hope you will choose to follow me on Twitter where from time to time I give my investment insights,” Icahn said in the letter. “I also intend to point out what I consider to be unconscionable actions by boards and discuss what remedies shareholders may take to change the situation.” Related: Billionaire Investor Carl Icahn Sets Eye on Apple Enroll Now for $5 Next Article Jason Fell Technology Entrepreneur Staff Fireside Chat | July 25: Three Surprising Ways to Build Your Brand –shares Image credit: activistinvesting.blogspot.com Director of the Entrepreneur Partner Studio Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Add to Queue Carl Icahn September 9, 2013 2 min read Billionaire Investor Carl Icahn Drops Campaign to Derail Dell’s Takeover Bid