Steve O’Meara is set to return to action on 14 September at York Hall – the venue where his last two fights have ended in spectacular first-round wins.The light-middleweight beat fellow West Londoner Ryan Toms there to become southern area champion last September and flattened Nathan Weise three months later.O’Meara, who was born in Shepherd’s Bush and lives in West Drayton, will feature in a six-round bout at the iconic Bethnal Green venue with his opponent yet to be confirmed.A victory would be another step towards a British title shot for the 28-year-old.“I’m on a roll at the York Hall at the moment with winning my last two fights in a round so it would be great to make it three in a row next month,” said O’Meara,“Saying that, if it it doesn’t come in the first round then I won’t be too gutted. I prefer to get in the rounds so that I’m building up the experience as I build towards a British title shot.”Follow West London Sport on TwitterFind us on Facebook
Cells are like miniaturized cities, with elaborate transportation systems ferrying their cargo to and fro (see Feb. 25 headline). Just like a city may have railroads, busses, cars and monorails, the cell has multiple kinds of transport motors: dyneins, kinesins, and myosins. Scientists have learned that most of the roadways are like one-way monorails: actin filaments and microtubules, upon which the vehicles travel in one direction. But what if a passenger needs to jump from one system to another? ‘ No problem; the cell has mastered the art of ridesharing with its own park-and-ride system. In the Dec. 2 issue of Current Biology1, this is described by Marcus Maniak in a Dispatch entitled “A park-and-ride system for melanosomes.” Melanosomes are organelles (somes) that carry melanin, the pigment chemical that allows some organisms, including fish and amphibians, to change their skin color to match their surroundings. For this to work, the melanosomes need to hitch rides either to the exterior of the cell or the interior. He pulls together several recent findings to describe how this all works:Together these findings suggested how melanosomes might move on actin filaments and showed that this type of motility is required for the even distribution of melanosomes within the cell. From these main observations, it became clear that, during aggregation, a cytoplasmic dynein motor carries melanosomes on the radially arranged microtubules towards the cell center (Figure 1B), while during dispersion a kinesin transports the granules to the periphery (Figure 1C), where they engage via a myosin V molecule with short actin filaments to be distributed further (Figure 1D). This switching of transport systems is a kind of miniature edition of modern urban traffic, where millions of workers leave the city centers in the evening on trains and board their cars at park-and-ride stations to complete their daily journey within the green peripheral belt. (Emphasis added in all quotes.)As if that were not amazing enough, it appears that the drivers “talk” to each other with a communication system:Although the work of Rodionov et al. has moved the field a large step further, there are obviously several issues that remain to be investigated. Exciting new findings addressing the coupling of motor molecules to the melanosome surface in other experimental animals open the possibility to speculate how the motors may talk to each other on a molecular level. At least for Xenopus there is now clear evidence that both dynein and kinesin couple to melanosomes via the dynactin complex. Moreover, both motors compete for the same protein component; this could allow one motor to gain access to the microtubule while the other is prevented from engaging successfully.He describes how this “tug-of-war” competition is actually a kind of way for the motors to negotiate the right-of-way. Additional factors that attach to the vehicles or trackways may assist in making sure the rules of the road are obeyed. “Thus,” he concludes, “further exciting results are on the way to complete the picture of how melanosomes switch from one transport system to the other.”1Marcus Maniak, “Dispatch: Organelle Transport: A Park-and-Ride System for Melanosomes,” Current Biology Vol 13, R917-R919, 2 December 2003.Maniak uses the word motor 22 times in his article, which is replete with other urban metaphors: transport system (see 09/26/2002 headline), etc. Moreover, there is no mention of evolution, Darwin, or of any mechanism that might explain how this elaborate, coordinated, interconnected system could have originated. Surprised? Every muscle move you make, every breath you take, every beat of your heart, and every one of your senses are dependent on molecular machines. The study of biological motors and molecular machines is the “biology of the future” that Bruce Alberts, President of the National Academy of Sciences and editor of Molecular Biology of the Cell has stated more than once (see 01/09/2002 headline). It was also a biology the likes of which Charles Darwin and his followers could not have imagined. Had Darwin seen into the future at what Year 2003 biologists would be detecting in life’s fundamental unit, the cell, and even in the simplest micro-organisms, he well could have developed cold shudders (see 01/29/2002 headline) severe enough to have frozen his evolutionary speculations to death.(Visited 19 times, 1 visits today)FacebookTwitterPinterestSave分享0
Riding on her Swiss Open triumph, ace Indian shuttler Saina Nehwal has regained the number three place in the latest world ranking.Saina, who missed a couple of tournaments early in the year because of a nagging ligament injury and then suffered early exits from the Korean Open and the All England Championships, notched up her first title of the season in Switzerland last week.The 21-year-old now has 69721.2637 points in her kitty and is currently behind Shixian Wang (83506.4) and Yihan Wang (73988.9106) at one and two respectively.The Swiss Open title was her third Grand Prix Gold title win after Chinese Taipei (2008) and the Indian Open (2010).The girl from Hyderabad also won four Super Series finals in Indonesia (twice), Singapore and Hong Kong over the last two years.In men’s singles, Commonwealth Games bronze medallist P Kashyap was at the 21st place with 38415.2559 points, while Ajay Jayaram moved to 28th. Anand Pawar and Arvind Bhat are at 42nd and 45th spot respectively.Commonwealth Games gold medal-winning women’s doubles pair of Jwala Gutta and Ashwini Ponnappa dropped one place to 19th spot, while Jwala and V Diju slipped two spots to 18th in mixed doubles.In men’s doubles, Rupesh Kumar and Sanave Thomas jumped seven places to be placed just outside the top 20 bracket at 21st place.
Summer getaways usually involve lush green hill stations, cocktails by the beach or swanky hotels. But how about trekking in the cold desert of Ladakh? Yes, it’s time to move beyond the regular sight-seeing and set off on a real adventure. “You don’t have to be an adrenaline junkie to,Summer getaways usually involve lush green hill stations, cocktails by the beach or swanky hotels. But how about trekking in the cold desert of Ladakh? Yes, it’s time to move beyond the regular sight-seeing and set off on a real adventure. “You don’t have to be an adrenaline junkie to enjoy adventure sports. Families too, are looking for such exciting holiday options, provided the trip is well organised,” says Keyur Joshi, COO, Makemytrip.Ride the tideFor an eventful vacation, head for whitewater rafting and camping on the shores. “You would feel an ultimate rush while floating through the scenic waterways,” says Suchi Smita of the whitewater action at Mori, which is a small village in Uttarakhand, located on the banks of Tons river. The proximity of Mussorie and Shimla is another attraction for the tourists visiting this side.Camping in surrounding forest and villages of Manali in Himachal is a bonus adventure for rafting enthusiasts who visit the Beas river in the region. While Indus and Zanskar rivers at Ladakh offer best stretches for a challenging raft trip, camping and rafting at Rishikesh are a safer bet. No wonder it’s a popular weekend getaway for families. Rishikesh also offers adventure sports such as rappelling and cliff jumping.Take to the waterRafting at Rishikesh is on till end of May,however, rivers such as Mori, Beas and Indus are accessible till themonth of June. One should carry shorts, t-shirts and floaters forrafting while track suits and sneakers for camping.View from the topIf you’re looking for an elevated experience, literally, and nature’s solitude, then a Himalayan sojourn is the answer. Ladakh (also known as little Tibet), the land of jagged peaks offers some of the most interesting treks. The lunar terrains of Leh and sand dunes of Nubra valley make your trekking efforts worth it and even more.Unlike the surreal beauty of Himalyas, treks in Himachal promises to be a cultural diaspora, with spotlight on popular Dhauladhar and Pirpanjal ranges. The quaint life of locales is charming and simple. The high altitude trek in the Kanchendzonga range (8,586 meters) of Sikkim and the tribal treks in Tawang, Dirang and the Tenga valley of Arunachal Pradesh are also some of the star treks. The trekking program should be organised by a registered travel agency. “We conduct an easy three-day trek to strenuous 20+day trek, offering complete arrangements from travel either by road or rail to all the necessary equipments, a trip leader and porters,” says Mandeep Dhillion, director of Synapses Adventures (www.synapses.in).Take a hikeThe best time to trek in Himalyas is from April to mid June, and then in September and October. One should be able to walk for at least 5-6 kms in the plains. A basic medical check up isadvisable, especially for first timers.Sea, I got you!Yes, it’s your chance to get upclose and personal with the marine species and beautiful, colourful coral reefs. Scuba diving is a treasured adventure sport for marine life enthusiasts. First time divers can also expect a spectacular view, provided the weather is good for visibility underwater. “The clear crystal water and pristine lagoons of Lakshadweep Islands are a safe option for diving newbies,” says a diving expert. Andaman Islands with its large schools of tropical fish, large pelagics, turtles and popular Manta Rays are a diving paradise. The island also boasts of liveboard diving. “The Havelock Islands at Andaman has excellent sites for divers such as Elephanta Beach, Inglis Island, and Buffalo Island,” shares Dhillon.Take the plungeThe diving season begins from mid-Januaryto mid-May with flat seas, excellent visibility and easy accessibilityto all the sites. August to November is also excellent time for diving.advertisement
By the time India and South Africa head out on to the turf at the R Premadasa Stadium on Tuesday, they will know exactly where they stand with regards to qualifying for the semi-finals.A Pakistan victory over Australia in the first game of the day will make sure that the AB de Villiers-led team is knocked out, leaving them to play spoilers for India. The Men in Blue will then have to win by a big enough margin to get past their arch-rivals on the net run rate.Click here to see entire coverage of World T20 On the other hand, if the Aussies extend their unbeaten streak in the World Twenty20, it’ll be all to play for. A victory for MS Dhoni’s men will mean they can progress without any NRR considerations; conversely, the Proteas, who have lost both their Super Eights games, could also make it through if they win convincingly.India have so far alternated below-average performances with the sublime, and will be hoping to arrest the trend. The dry and slow track here will suit the Indians’ game much more than South Africans’, especially in the bowling department.South Africa need to win against India to have any chance of making it to the semi-finalsTheir main pacers, Dale Steyn and Morne Morkel, are two of the best in the world in any format. But not only are the batsmen used to facing them in the Indian Premier League, their extra pace could actually work against South Africa, as shown by Pakistani tailender Umar Gul’s rapid 32 in their first Super Eights game.advertisementTheir batting, too, is looking short on confidence, having struggled to 133 and 146 in their two games. The key to restricting them has been the deployment of extra spinners like Pakistan’s Raza Hasan and Australia’s Xavier Doherty.For India, the resounding victory over Pakistan on Sunday has made life much easier than it was after the demoralising defeat to Australia last week.After a fast start, the crucial passage of play was the introduction of Lakshmipathy Balaji’s medium pace, which got rid of Shahid Afridi, and spinners R Ashwin and Yuvraj Singh followed up well.Virender Sehwag showed enough class in his 29 on Sunday to merit a retention in the XI, so Dhoni is likely to go into the game with his tried-and-tested seven batsmen and four bowlers combination, with the only question being whether he wants to include off-spinner Harbhajan Singh to trouble the Proteas batsmen, in place of one of the seamers.In that case, the big call will be whether to drop the all-round skills of Irfan Pathan, the attack leader in Zaheer Khan, or the inform Balaji. The stage is set for a match that will more likely than not decide who joins the Aussies in the next round. Now it is up to the stars on either side to stand up and be counted.India vs South Africa, Live from Colombo, on STAR Cricket from 7:30 pm
PORT ST. LUCIE, Fla. — Like a lot of New York Mets fans, Manager Terry Collins is tired of waiting for a playoff run.“We’ve been sitting around for four years asking everybody to be patient and even the players,” Collins said Feb. 21 after the first workout for pitchers and catchers.“Well, it’s time,” he said. “We’ve got guys now that have been in the big leagues for four and five years. It’s time for them to step up and play the game the way everybody expects it to be played.”A day earlier, Mets General Manager Sandy Alderson said five years was enough to turn around a franchise, regardless of payroll constraints.The Mets have not made the playoffs since 2006 and have not finished above .500 since 2008. The Alderson-Collins regime is heading into its fifth year.New York was 79-83 and finished third in the NL East in 2014 while ace Matt Harvey and closer Bobby Parnell were out with injuries and star third baseman David Wright was ailing.“What we accomplished last year with the fact that we didn’t have our No. 1 starter, we didn’t have our closer, our third baseman played hurt most of the season,” Collins said.“There were a lot of positives going into the offseason and I say, Hey, it’s time,’” he said.The Mets were relatively quiet this offseason. They signed right fielder Michael Cuddyer to a two-year, $21 million deal and brought in John Mayberry Jr. to bolster the bench.But the team expects to have Harvey and Wright healthy for a full year and hope to have Parnell back between mid-April and early-May.“We should match up against a lot of teams, now we just have to go play,” Collins said. “It’s all about execution. … There’s no reason why, if we can’t play up to expectations and what we think the caliber of players we have, we’ll be playing in October.”TweetPinShare0 Shares
May 12, 2008 Congratulations to the April 6. workshop participants upon their graduation on Friday, May 9. 2008: [from left] Shane Hayden, Gregg Elliott, Daniel Copperman, Yong Su Park and Antonio De Biase. [Photo & text: sa]